Symposium A2
Systems approaches to modeling the contribution of transporters in drug disposition, response and toxicity

Tuesday 23 May 2017
08:00-11:00
Stockholmsmässan : K1

Introduction

This session brings together a world-class group of scientists who will give a range of presentations that focus on experimental and computational models to understand the role of drug transporters in drug toxicity and response with a particular focus on the blood brain barrier.

Co-Chair(s): Mikko Niemi (Finland) and Rada Savic (USA)

Programme

08:00 – 08:10 General introduction
Mikko Niemi, University of Helsinki, Finland

08:10 – 08:45 Quantifying the impact of transporters on cellular drug permeability
Per Artursson, University of Uppsala, Sweden

08:45 – 09:20 Modeling and prediction of the effect of transporters on differences of unbound drug concentrations between the plasma, brain and cerebrospinal fluid
Yuichi Sugiyama, RIKEN Innovation Center, Japan

09:20- 09:40 BREAK

09:40- 10:15 Uptake of cocaine, opioids and other organic cations at the BBB 
Jean-Michel Scherrmann, Paris Descartes University, France

10:15 – 10:50 Organic cation uptake of GHB at the BBB: incorporation of brain transport in modeling of PK/PD
Marilyn Morris, University at Buffalo, USA

10:50 – 11:00 Concluding remarks
Rada Savic, University of California San Francisco, USA